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Gut-Brain Connection

23 Jul

Have you ever had a “gut-wrenching” experience? Do certain situations “make you nauseous”? We use these expressions to describe emotional reactions because emotions often trigger symptoms in the gastrointestinal tract. Nerves, stresses, mental problems, and other psychological factors can wreak havoc in the gut (see Your Gut Reactions). That’s because the brain and the gastrointestinal system are intimately connected.

The entire journey of food through the 30-foot-long digestive tract is quarterbacked by a remarkable communication network known as the enteric nervous system (ENS). This intricate nerve complex is located in the gut wall and communicates with the brain via the spinal cord. In turn, hormones, neuro­transmitters, and connections to the central nervous system that affect muscles, mucosa, and blood vessels in the digestive tract influence the ENS.

The ENS cells in the lining of the gut communicate with the brain, first via the sympathetic nerves that pass to and from the gut through transformers called sympathetic ganglia. These nerves connect to the spinal cord and then to the base of the brain. In addition, parasympathetic nerves link to the base of the brain via the vagus nerve from the upper gut or the sacral nerves from the colon. The gut and brain use chemicals called neurotransmitters to send electrochemical messages to one another by way of these nerves. Scientists say that this sophisticated “gut-brain” system is nearly equal in size and complexity to the body’s central nervous system.

Imaging studies of the brain show that functional GI symptoms are not necessarily the result of dysfunction in the bowel, but may be due to disturbances in brain-gut pathways that lower pain thresholds, affect movement through and contractions of the GI tract, and alter behavior.

We know that the brain has a direct effect on the stomach if only because the thought of eating can set off the stomach’s appetite juices even before food gets there. But the action goes both ways. A troubled intestine can send signals to the brain just as a troubled brain can send signals to the gut. A patient’s distressed gut might, therefore, be as much the cause as the product of depression or anxiety. 

Our relationship with water – fascinating

11 Jul

humanbasic1.jpgJuly 10, 2007


Small, Yes, but Mighty:


 The Molecule Called



Some 380 million years ago, a few pioneering vertebrates first made the leap from water to land. And today, tens of millions of their human descendants seek summer amusement by leaping the other way. According to the travel industry, close to 90 percent of vacationers choose as their holiday destination an ocean, lake or other scenic body of water.

We may have lungs rather than gills, and the weaker swimmers among us may be perfectly capable of drowning in anything deeper than a bathtub, yet still we feel the primal tug of the tide. Consciously or otherwise, we know we’re really all wet.

As fetuses, we gestate in bags of water. As adults, we are bags of water: roughly 60 percent of our body weight comes from water, the fluidic equivalent of 45 quarts. Our cells need water to operate, and because we lose traces of our internal stores with every sweat we break, every breath and excretion we out-take, we must constantly consume more water, or we will die in three days.

Thirstiness is a universal hallmark of life. Sure, camels can forgo drinking water for five or six months and desert tortoises for that many years, and some bacterial and plant spores seem able to survive for centuries in a state of dehydrated, suspended animation. Yet sooner or later, if an organism plans to move, eat or multiply, it must find a solution of the aqueous kind.

Life on Earth arose in water, and scientists cannot imagine life arising elsewhere except by water’s limpid grace. In the view of Geraldine Richmond, a chemistry professor at the University of Oregon who often talks to the public on the wonders of water, Mark Twain put it neatest: “Whiskey is for drinking; water is for fighting over.”

Behind water’s peerless punch, and the reason it rather than alcohol or any other lubricant serves as the elixir of life, is the three-headed character whose chemical name we all know: H2O. Scientists observe that when two atoms of hydrogen conjoin with one of oxygen, the resulting molecule displays a spectacular range of powers, gaining the mightiness of a molecular giant while retaining the speed and convenience of a molecular mite.

“Water behaves very differently from other small molecules,” said Jill Granger, a professor of chemistry at Sweet Briar College in Virginia. “If you want something else with similar properties, you’d end up with something much bigger and more complex, and then you’d lose the advantages that water has in being small.”

Because of water’s atomic architecture, the tendency of its comparatively forceful oxygen centerpiece to cling greedily to electrons as it consorts with its two meeker hydrogen mates, the entire molecule ends up polarized, with slight electromagnetic charges on its foreside and aft. Those mild charges in turn allow water molecules to engage in mild mass communion, linking up with one another and with other molecules, too, through an essential connection called a hydrogen bond. The hydrogen bond that attracts water to water and to other like-minded players is subtler than the bond that ties each water molecule’s atoms together. But subtlety breeds opportunity, and from hydrogen bonds many of water’s major and minor properties flow.

With their hydrogen bonds, water molecules become sticky, cohering as a liquid into droplets and rivulets and following each other around like a jiggling conga line. Such stickiness means that water is drawn to the inner plumbing of plants and will crawl up the fibrous conduits to hydrate even the crowns of redwood trees towering hundreds of feet above ground.

Pulled together by hydrogen bonds, water molecules become mature and stable, able to absorb huge amounts of energy before pulling a radical phase shift and changing from ice to liquid or liquid to gas. As a result, water has surprisingly high boiling and freezing points, and a strikingly generous gap between the two. For a substance with only three atoms, and two of them tiny little hydrogens, Dr. Richmond said, you’d expect water to vaporize into a gas at something like minus 90 degrees Fahrenheit, to freeze a mere 40 degrees below its boiling point, and to show scant inclination to linger in a liquid phase.

That’s what happens to hydrogen sulfide, a similarly sized molecule but with its two hydrogen atoms fastened to sulfur rather than to oxygen; on our temperate world, hydrogen sulfide has long since reached its boiling point and exists as a foul-smelling gas. Same for the tidy troika of carbon dioxide: low freezing point, low boiling point, and, poof, it’s up in the air. But given its vivid power of hydrogen bonding, water proves less flighty and fickle, with a boiling point at sea level of 212 degrees Fahrenheit, and a full 180 degrees lying between the tempest of a teapot and the tinkling of an ice cube at 32 degrees. A vast temperature span over which water molecules can pool and cling as the liquid assets we love best.

We rely in myriad ways on water’s fluid forbearance, its willingness to take the heat without blinking. Earth’s oceans and lakes soak up huge quantities of solar radiation and help moderate the climate. As sweat evaporates from our skin, it wicks away large amounts of excess heat.

Water also serves as a nearly universal solvent, able to dissolve more substances than any other liquid. It can act as an acid, it can act as a base, with a pinch of salt it is the solution in which the cell’s thousands of chemical reactions take place.

At the same time, water’s gregariousness, its hydrogen-bonded viscosity, helps lend the cell a sense of community.

“Water acts as the contact between biological molecules, not just separating them, but imparting information among them,” said Martin Chaplin, a professor of applied science who studies the structure of water at London South Bank University. “In an aqueous environment, all the molecules are able to feel the structure of all the other molecules that are present, so they can work as whole rather than as individuals.”

There’s no end to water’s chemical kinkiness, including the way it freezes from the top down and becomes buoyant as it chills. Most substances shrink and get denser and heavier as they cool, and expand and lighten as they melt. Water bucks the norm, and is lighter and airier as ice than when liquid, and so in winter marine life can find liquid haven beneath the floating blanket of ice, and so in summer ice cubes bob and clink in your glass of lemonade. Bottoms up.

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